Mechanics of Biomolecules

From atomic workings of nucleic-acids up to protein’s nanomechanical maps.

Biomolecular mechanics play a pivotal role in a myriad of biological processes, influencing everything from the replication and repair of genetic material to the interaction between various biomolecules inside the cell. By deciphering these mechanical properties, we aim to shed light on the inner workings of biological systems, offering physical insights essential for unlocking the mysteries of life itself.

A prime example of our focus lies in the study of double-stranded nucleic acids (DNA and RNA), where mechanical properties dictate crucial biological functions. From the localized movements of individual base pairs upon protein binding to the global folding of genome-length polymers, these biomolecules exhibit a broad spectrum of deformations across multiple length scales. Despite intensive research efforts, bridging the dynamics across these scales remains a formidable challenge.

In our pursuit, we’ve developed a simulation strategies that unveils the atomic underpinnings of nucleic acid mechanics, resolving long-standing paradoxes and offering profound insights. By synergistically combining simulation with experimental techniques such as Atomic Force Microscopy (AFM), Optical Tweezers (OT), and Magnetic Tweezers (MT), we connect our findings to processes occurring on larger scales. Some milestone achievements include: